Gene

alox5b.3

ID

ZDB-GENE-050522-330

Name

arachidonate 5-lipoxygenase b, tandem duplicate 3

Symbol

alox5b.3 Nomenclature History

Previous Names

ALOX3c (1)
cb171 (1)
sb:cb171
zgc:110251

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have iron ion binding activity and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Predicted to be involved in oxidation-reduction process. Human ortholog(s) of this gene implicated in arteriosclerosis; asthma; pancreatic cancer; pulmonary hypertension; and pulmonary tuberculosis. Is expressed in EVL and periderm. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb171 (2 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With alox5b.3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
asthma	Alliance	{Asthma, diminished response to antileukotriene treatment in}	600807
		{Atherosclerosis, susceptibility to}

Associated With alox5b.3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR020833	Lipoxygenase, iron binding site
Conserved_site	IPR020834	Lipoxygenase, conserved site
Domain	IPR001024	PLAT/LH2 domain
Domain	IPR013819	Lipoxygenase, C-terminal
Family	IPR000907	Lipoxygenase
Family	IPR001885	Lipoxygenase, mammalian
Homologous_superfamily	IPR036226	Lipoxigenase, C-terminal domain superfamily
Homologous_superfamily	IPR036392	PLAT/LH2 domain superfamily

Domain Details Per Protein

Protein	Length	Lipoxigenase, C-terminal domain superfamily	Lipoxygenase	Lipoxygenase, conserved site	Lipoxygenase, C-terminal	Lipoxygenase, iron binding site	Lipoxygenase, mammalian	PLAT/LH2 domain	PLAT/LH2 domain superfamily
UniProtKB:F1R442 InterPro	676
UniProtKB:Q503R7 InterPro	676

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	alox5b.3-201 (1) Ensembl	Ensembl	2,576 nt	Select Tool
mRNA	alox5b.3-204 (1) Ensembl	Ensembl	4,090 nt	Select Tool ZFIN BLAST
ncRNA	alox5b.3-002 (1) Ensembl	Ensembl	434 nt	Select Tool
ncRNA	alox5b.3-003 (1) Ensembl	Ensembl	962 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations